Tris-EDTA (TE) is a high quality, reliable and convenient solution which incorporates a buffer, Tris and a chelanting agent, EDTA. EDTA avoids the degradation of DNA and RNA chelating magnesium or other divalent metal ions.
Generally, TE is used to solubilize DNA and RNA, protecting it from degradation.
Moreover, in the fixation with immunohistochemichal, formalin and other aldehydes, fixation generates protein cross-links that mask the antigenic sites, giving weak positives or false negatives.
With TE buffer the protein cross-links are broken, antigens and epitopes are unmasked therefore enhancing the intensity of staining of antibodies.
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