ExpressMAX™ Expression-ready Human GPCR ORF Clone
Beta-2-adrenergic Receptor is a member of beta adrenergic Receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. It is located primarily in the CNS, heart, kidney and muscle where it is involved in smooth muscle relaxation (e.g. bronchodilation). ADRB2 is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. Different polymorphic forms, point mutations and/or downregulation of the gene are associated with nocturnal asthma, obesity and type 2 diabetes.
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