ExpressMAX™ Expression-ready Human GPCR ORF Clone
Bile Acid GPCR (GPBAR1) functions as a cell surface Receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway and internalization of the Receptor. The Receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in three transcript variants encoding the same protein.
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