Cannabinoid 2 Receptor

Manufacturer: Canvax
Availability: in stock 0 item(s)
Product Code: P21582014
SKU: G0517-Plus
UOM: 15 µL (12-well plate) + 0.2 mL

ExpressMAX™ Expression-ready Human GPCR ORF Clone

Cannabinoid 2 Receptor inhibits adenylate cyclase activity through their Gi/Gαo subunits in a dose dependent for its ligand. The principal endogenous ligand for the CNR2 receptor is 2-archidonoylglycerol. Through their Gβϒ subunits, CNR2 Receptor is coupled to the MAPK-ERK pathway, which regulates cellular processes in both mature and developing tissues. It is localized on immune cells such as monocytes, macrophages, B-cells and T-cells. It is also found in the brain, on microglia but not in neurons and the gastrointestinal system, where it modulates intestinal inflammatory response.

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