ExpressMAX™ Expression-ready Human GPCR ORF Clones
It is a chemokine receptor belonging to the GPCR superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. It is most closely related to RBS11 and the MIP1-alpha/RANTES Receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for the gene.
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