ExpressMAX™ Expression-ready Human GPCR ORF Clones
It is a Receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. This Receptor, encoded by the gene CCR2, mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. The gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
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