MITF (M2A1) Monoclonal Antibody

Manufacturer: Bioss Inc
Availability: in stock 0 item(s)
Product Code: P22672844
SKU: BSM-51339M
UOM: 100ul

Product name: MITF (M2A1) Monoclonal Antibody
Applications: WB
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Mouse
Source: This MITF antibody is generated from a mouse immunized with a recombinant protein of human MITF.
Clonality: Monoclonal
Clone: #M2A1
Isotype: IgG1
Concentration: 0.5ug/ul
Purification: Purified by Protein G.
Storage buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage condition: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Gene ID: 4286
Swiss Prot: O75030
Synonyms: MI; WS2; CMM8; WS2A; bHLHe32; Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; MITF
Background: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

*Image title: Lane 1: A431 cell lysates probed with MITF (M2A1) Monoclona Antibody, Unconjugated (bsm-51339M) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.

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