Product name: ADAM17 (9E7) Monoclonal Antibody
Applications: WB, FCM, IF(ICC)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Source: Recombinant human ADAM17 protein, around 700-824aa.
Clonality: Monoclonal
Clone: #90000000
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage buffer: Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage condition: Store at -20°C for 12 months
TARGETGene ID: 6868
Swiss Prot: P78536
Synonyms: Disintegrin and metalloproteinase domain-containing protein 17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; CD156B; NISBD1; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme.
Background: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
*Image title: Jurkat cell lysate probed with ADAM17 (9E7) Monoclonal Antibody, Unconjugated (bsm-52009R) at 1:1000 overnight at 4˚C. Followed by a conjugated secondary antibody
For more details, please follow https://www.biossusa.com/products/bsm-52009r
