Product name: HDAC2 (3B7) Monoclonal Antibody
Applications: WB, IHC-P, IF(ICC)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Source: Recombinant human HDAC2 protein, around C-terminal 150aa.
Clonality: Monoclonal
Clone: #3B7
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage buffer: Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage condition: Store at -20°C for 12 months
TARGET
Gene ID: 3066
Swiss Prot: Q92769
Synonyms: HD2; RPD3; YAF1; Histone deacetylase 2; HDAC2
Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
*Image title: Lane 1: 293T Cell lysates; Lane 2: K562 lysates; probed with HDAC2 (3B7) Monoclonal Antibody (bsm-52082R) at 1:1000 overnight at 4˚C. Followed by a conjugated secondary antibody.
For more details, please follow https://www.biossusa.com/products/bsm-52082r
