HDAC8 (4C3) Monoclonal Antibody

Manufacturer: Bioss Inc
Availability: in stock 0 item(s)
Product Code: P22192858
SKU: BSM-52088R
UOM: 100ul

Product name: HDAC8 (4C3) Monoclonal Antibody
Applications: WB, IHC-P, IF(ICC)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Source: Recombinant human HDAC8 protein, around N-terminal 150aa.
Clonality: Monoclonal
Clone: #4C3
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage buffer: Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage condition: Store at -20°C for 12 months

Gene ID: 55869
Swiss Prot: Q9BY41
Synonyms: HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1; Histone deacetylase 8; HDAC8

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

*Image title: Lane 1: Hela; Lane 2: K562 lysate probed with HDAC8 (4C3) Monoclonal Antibody (bsm-52088R) at 1:1000 overnight at 4˚C. Followed by a conjugated secondary antibody.

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