PI3K p85 (5C11) Monoclonal Antibody

Manufacturer: Bioss Inc
Availability: in stock 0 item(s)
Product Code: P22872867
SKU: BSM-33219M
UOM: 100ul

Product name: PI3K p85 (5C11) Monoclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human, Mouse, Rat, Chicken
Conjugation: Unconjugated
Host: Mouse
Source: Recombinant mouse PI3K p85 Protein
Immunogen range: 1-110/724
Clonality: Monoclonal
Clone: #5C11
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein G.
Storage buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage condition: Store at -20°C for 12 months

Gene ID: 18708
Swiss Prot: P26450

Synonyms: Phosphatidylinositol 3-kinase regulatory subunit alpha; Pik3r1; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

Background: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).

*Image title: BRL-3A cell lysates probed with PI3K p85 (5C11) Monoclonal Antibody, unconjugated (bsm-33219M) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.

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