PRODUCT NAME: STAT3 (3F5) Monoclonal Antibody
APPLICATIONS: WB, IHC-P
SPECIFICITY: KO-Validated
REACTIVITY: Human, Mouse, Rat
CONJUGATION: Unconjugated
HOST: Mouse
CLONALITY: Monoclonal
CLONE: #3F5
ISOTYPE: IgG
CONCENTRATION: 1ug/ul
PURIFICATION: Purified by Protein G.
STORAGE BUFFER: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
STORAGE CONDITION: Store at -20°C for 12 months..
TARGET
GENE ID: 6774
SWISS PROTP: 40763
SYNONYMS: Signal transducer and activator of transcription 3; STAT3; Acute-phase response factor; APRF
BACKGROUND: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genesPubMed:12359225. Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476).
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